Categories
GLP1 WEIGHT LOSS

GLP-1 and Gallstones: Was It Mounjaro or the Weight Loss? (UK)

Did Mounjaro Cause My Gallstones? GLP-1, Rapid Weight Loss and the Real Risk (UK Guide)

Author context: I lost 6 stone using Mounjaro (GLP-1) over 12 months and later required emergency NHS gallbladder surgery in February 2026. This article explains what the science says — calmly and responsibly.

Short answer: Mounjaro does not directly create gallstones. However, rapid weight loss — which often occurs during GLP-1 treatment — is a recognised risk factor for gallstone formation.

If you’re asking this question, it’s usually because something scary has happened. I asked it too.

You can read my full emergency surgery story here →

Start here: If you’re dealing with gallbladder symptoms (or recovery after removal) and want the full UK guide — symptoms, red flags, A&E triggers, surgery, recovery, diet and GLP-1 context — use the mega hub below.

GLP-1, Gallstones & Gallbladder Removal (UK): Mega FAQ Guide →

Does Mounjaro cause gallstones?

Mounjaro does not directly form gallstones. Gallstones develop when bile becomes overly concentrated with cholesterol and the gallbladder does not empty effectively. Rapid fat loss increases this risk.

  • Weight loss increases cholesterol secretion into bile
  • Gallbladder emptying may slow during caloric restriction
  • Cholesterol crystals can accumulate and solidify

This mechanism is not unique to GLP-1 medications. It is also observed after bariatric surgery and crash dieting.

Why rapid weight loss increases gallstone risk

When body fat is broken down quickly, stored cholesterol is mobilised. The liver processes this and secretes more cholesterol into bile.

At the same time:

  • The gallbladder may contract less frequently
  • Bile may remain in the gallbladder longer
  • Crystallisation becomes more likely

In simple terms: the faster weight drops, the more bile chemistry can shift toward stone formation in susceptible individuals.

Table: What actually drives gallstone risk?

Factor Level of Influence Why It Matters
Rapid weight loss High Changes bile cholesterol concentration
GLP-1 medication itself Indirect Accelerates fat loss in some individuals
Crash dieting High Extreme calorie deficit shifts bile chemistry
Genetic predisposition Variable Family history affects bile composition

Are gallstones listed as a GLP-1 side effect?

Yes — gallbladder-related events appear in medication documentation. However, this reflects association with weight loss rather than a direct stone-forming effect.

Important nuance:

  • Most GLP-1 users do not develop gallstones
  • Risk increases with faster weight loss
  • Individual biology matters

My case: context matters

I lost 6 stone over 12 months. Then I experienced:

  • Upper right abdominal pain
  • Back pain under the shoulder blade
  • Symptoms that felt like trapped wind at first

Blood tests showed inflammation. Imaging confirmed obstruction. Surgery followed.

That experience forced me to separate emotion from physiology.

Who is most at risk?

  • People losing weight rapidly (especially more than 1–2kg per week)
  • Individuals with previous gallbladder sludge
  • Those with metabolic syndrome history
  • People combining GLP-1 with extreme calorie restriction

Should you stop Mounjaro if gallstones develop?

Do not stop prescribed medication without medical advice.

Management depends on:

  • Severity of symptoms
  • Presence of infection
  • Whether surgery is required
  • Your clinician’s risk-benefit assessment

Many people continue GLP-1 safely after gallbladder removal under supervision.

When to seek urgent medical help

  • Severe upper right abdominal pain lasting more than 1–2 hours
  • Fever or chills
  • Yellowing of the eyes (jaundice)
  • Persistent vomiting

If symptoms escalate, seek urgent care.

Digestive support during recovery (educational only)

After surgery and during dietary transition, some people explore gentle digestion support.

Browse digestive support options at Lily & Loaf

Supplements do not prevent gallstones and do not replace medical care.

FAQs

1. Can GLP-1 medications increase gallstone risk?

Yes indirectly, through accelerated weight loss in some individuals.

2. Is rapid weight loss the main factor?

Speed of fat loss appears to be a major driver.

3. Are gallstones common on Mounjaro?

They are recognised but not common for most users.

4. Can gallstones resolve without surgery?

Small stones may remain silent, but obstructive stones require treatment.

5. Can you restart GLP-1 after gallbladder removal?

Often yes, under clinician supervision.

6. Does diet influence gallstone risk?

Extreme calorie restriction can increase risk.

7. Does slower weight loss reduce risk?

Gradual weight loss may reduce bile chemistry disruption.

8. Are women more at risk?

Gallstones are more common in women overall.

9. Can gallstones cause chest pain?

Yes, pain can radiate and mimic other conditions.

10. Is back pain common with gallstones?

Right shoulder blade pain is common.

11. Should everyone on GLP-1 worry?

No. Most people do not develop gallstones.

12. Does exercise reduce risk?

Regular activity may support metabolic health.

13. Can dehydration influence bile concentration?

Hydration supports overall digestive health.

14. Are older adults at higher risk?

Risk increases with age.

15. Is NHS gallbladder surgery common?

Yes, cholecystectomy is a common emergency procedure in the UK.

Disclaimer: This article shares lived experience and educational context. It does not replace professional medical advice.

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Categories
GLP1 WEIGHT LOSS

ChatGPT Saved My Life: GLP-1, Gallstones and Emergency Gallbladder Surgery (UK Story)

GLP-1, Rapid Weight Loss and Gallstones: My Emergency Gallbladder Surgery Story (UK)

Why you can trust this story: I lost 6 stone using Mounjaro (GLP-1) in 12 months and had emergency NHS gallbladder surgery in February 2026. I documented the experience publicly, including the symptoms I nearly ignored.

Medical note: This is lived experience + educational context, not medical advice. If you’re in severe pain or worried, contact 111 or go to A&E.

Two days.

That’s what the surgeon told me — if I’d waited another 48 hours, my gallbladder would likely have ruptured.

I’d lost 6 stone using Mounjaro (GLP-1). I felt healthier than I had in years. Then right-side pain, back pain, and symptoms I almost dismissed as “trapped wind” escalated into an emergency.

Start here: If you’re dealing with gallbladder symptoms (or recovery after removal) and want the full UK guide — symptoms, red flags, A&E triggers, surgery, recovery, diet and GLP-1 context — use the mega hub below.

GLP-1, Gallstones & Gallbladder Removal (UK): Mega FAQ Guide →

My Surgery Story (Video Diary)

This is the video diary where I walk through the timeline, the symptoms, and the NHS emergency surgery process.

Why this matters for Google (and real humans): it’s time-stamped, first-hand documentation of symptoms → escalation → emergency treatment. That’s experience, not theory.

When to go to A&E (quick checklist)

Seek urgent medical care now if you have:

  • Severe upper right abdominal pain lasting more than 1–2 hours
  • Pain spreading to your back or right shoulder blade
  • Fever, chills, or shaking
  • Yellowing of eyes/skin (jaundice)
  • Persistent vomiting or worsening pain

Does rapid weight loss cause gallstones?

Yes, rapid weight loss increases the risk of gallstones. When weight drops quickly, the liver releases more cholesterol into bile while the gallbladder may empty less often. This can allow crystals to form and develop into gallstones.

This risk is commonly discussed in relation to:

  • Very low calorie diets
  • Bariatric surgery
  • Rapid fat loss programmes
  • GLP-1 assisted weight loss

What does a gallbladder attack feel like?

A gallbladder attack usually causes sudden, severe pain in the upper right abdomen. The pain may spread to the back or right shoulder blade and often worsens after eating fatty foods. Episodes typically last one to several hours and may include nausea.

  • Sharp pain under right ribs
  • Back or shoulder blade pain
  • Nausea
  • Pain lasting more than 1 hour
  • Often worse after fatty meals

Did Mounjaro cause my gallstones?

Here’s the responsible way to think about it:

  • Rapid weight loss itself is a known risk factor for gallstones.
  • GLP-1 medications can lead to significant, sustained weight loss — which may increase risk indirectly for some people.

In my case, the most likely driver was the speed of fat loss combined with personal susceptibility. That’s why this topic needs calm, evidence-aware framing — not panic.

NHS emergency process (what happened)

I’m not sharing every clinical detail publicly, but the pattern looked like this:

  • Symptoms escalated beyond “indigestion”
  • A&E assessment + bloods to check inflammation/infection markers
  • Imaging confirmed gallstones/obstruction
  • Emergency surgery (cholecystectomy) followed

If you’re reading this mid-pain: don’t rely on blogs (including mine). Use 111/A&E when symptoms match the checklist above.

Life after gallbladder removal: what to expect

Without a gallbladder, bile flows directly from liver to intestine instead of being stored and released in bursts. Most people adapt over time, but digestion can be “weird” during recovery.

Table snippet target: common changes after gallbladder removal

Change Why it can happen
Loose stools / diarrhoea Bile reaches the gut more continuously and can irritate the colon
Fat sensitivity No bile storage “surge” for large fatty meals
Bloating / discomfort Digestive system adjusting to new bile flow pattern
Urgency after meals Some foods trigger quicker gut response during recovery

Can you take Mounjaro after gallbladder removal?

In many cases, yes — but only under medical supervision. After gallbladder removal, bile flows directly from the liver to the intestine. Most people adapt over time, and some continue GLP-1 medications successfully. Your surgeon/prescriber should guide timing and dose changes.

Digestive support (educational context only)

During recovery, I focused on basics first (food choices, meal size, and gradual reintroduction). Some people also explore non-prescription digestive support during dietary transitions.

Optional digestion support (not medical treatment): Some people choose digestive enzyme blends to support general digestion while they work out what foods feel “normal” again.

Browse digestion support options at Lily & Loaf

Important: Supplements don’t treat gallstones or replace medical care. If symptoms persist, talk to your clinician.

Related reading

FAQs (People Also Ask)

1) Does rapid weight loss cause gallstones?

Rapid weight loss increases gallstone risk because bile chemistry changes and the gallbladder may empty less often, making stone formation more likely.

2) What does a gallbladder attack feel like?

It’s typically sudden, severe upper right abdominal pain that can spread to the back or right shoulder blade, often after fatty food, lasting one to several hours.

3) Gallbladder attack vs trapped wind — how can you tell?

Gallbladder pain tends to be persistent, severe, and may radiate to the back/shoulder; trapped wind often shifts, improves with movement/burping, and isn’t usually triggered repeatedly after fatty meals.

4) Can gallbladder pain feel like chest pain?

Yes. Some people feel pain behind the breastbone or in the upper abdomen, which is why severe symptoms should be assessed urgently to rule out other causes.

5) How long does a gallbladder attack last?

Often one to several hours. Pain lasting more than 1–2 hours (especially with fever, vomiting, or jaundice) should be assessed urgently.

6) Where is gallbladder pain located?

Commonly in the upper right abdomen under the ribs, sometimes spreading to the back or right shoulder blade.

7) What foods trigger gallbladder attacks?

Fatty meals are a common trigger. Individual triggers vary, especially during periods of gallbladder irritation or bile duct obstruction.

8) What should I do during a suspected gallbladder attack?

If pain is severe, persistent, or worsening, seek medical advice urgently. Don’t “wait it out” if symptoms match the A&E checklist.

9) When should I go to A&E for gallbladder pain?

If pain lasts more than 1–2 hours, or you have fever, vomiting, chills, or jaundice, go to A&E/seek urgent care.

10) What happens if a gallbladder bursts?

A ruptured gallbladder can leak bile into the abdomen and cause serious infection (peritonitis). This is an emergency requiring urgent treatment.

11) Can gallstones cause back or shoulder pain?

Yes. Pain can “refer” to the back or right shoulder blade, which is why it’s often mistaken for muscle strain.

12) Can GLP-1 medications increase gallstone risk?

Rapid weight loss is a known risk factor. GLP-1 medications may increase risk indirectly in some people because they can lead to substantial weight loss.

13) Did Mounjaro cause my gallstones — or was it the weight loss?

For many people, the speed of weight loss is the biggest driver of risk. Medication may contribute indirectly through accelerated fat loss.

14) Can you take Mounjaro after gallbladder removal?

Many people do, but it must be guided by your clinician. Timing can depend on your recovery and any complications.

15) How long after gallbladder removal can you restart GLP-1?

This varies. Some clinicians prefer waiting until you’re fully recovered and your digestion stabilises. Follow your surgeon/prescriber’s advice.

16) What are common side effects after gallbladder removal?

Temporary loose stools, bloating, and fat sensitivity are common during adaptation. Most people improve over time.

17) Why do some people get diarrhoea after gallbladder removal?

Continuous bile flow can irritate the colon in some people, leading to loose stools or diarrhoea.

18) What is bile acid diarrhoea and can it happen after surgery?

Bile acid diarrhoea happens when excess bile acids reach the colon and trigger watery diarrhoea. It can occur after gallbladder removal and is treatable — ask your clinician.

19) What diet helps after gallbladder removal?

Many people do best starting with smaller meals and lower fat foods, then reintroducing fats gradually as tolerance improves.

20) Do digestive enzymes help after gallbladder removal?

Some people choose enzymes to support general digestion during dietary changes. They’re not a treatment for gallstones or surgery complications — think “support,” not “fix.”

Disclaimer: This article shares personal experience and educational context. It does not replace professional medical advice. If you have severe symptoms, fever, jaundice, persistent vomiting, or escalating pain, seek urgent medical care.

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